Observe patients for signs of respiratory depression Which might be bigger than normally envisioned and reduce the dosage of DILAUDID INJECTION and/or the muscle mass relaxant as essential.
If a choice is made to treat significant respiratory melancholy during the bodily dependent affected individual, administration on the antagonist must be initiated with treatment and by titration with lesser than normal doses in the antagonist.
There exists a romantic relationship amongst escalating hydromorphone plasma concentration and expanding frequency of dose-connected opioid adverse reactions including nausea, vomiting, CNS consequences, and respiratory depression.
If this SPL incorporates inactivated NDCs mentioned by the FDA initiated compliance action, They are going to be specified therefore.
Tolerance can be a physiological condition characterised by a diminished response to some drug soon after repeated administration (i.e., a higher dose of a drug is necessary to create precisely the same outcome that was once received in a reduce dose).
Misuse and abuse of DILAUDID INJECTION will increase danger of overdose, which can bring about central anxious procedure and respiratory melancholy, hypotension, seizures, and death. The chance is improved with concurrent abuse of DILAUDID INJECTION with Liquor and/or other CNS depressants.
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DILAUDID INJECTION exposes people together with other users towards the challenges of opioid addiction, abuse, and misuse, which may lead to overdose and death.
Results around the Cardiovascular Technique Hydromorphone generates peripheral vasodilation which may result in orthostatic hypotension or syncope, manifestations of histamine release and/or peripheral vasodilation could include things like pruritus, flushing, red eyes, and sweating and/or orthostatic hypotension.
you need to know that hydromorphone injection may possibly make you drowsy. Tend not to push an auto or run equipment until eventually you know how this medication has an effect on you.
If concomitant use is warranted, carefully observe the individual, notably for the duration of cure initiation and dose adjustment. Discontinue DILAUDID INJECTION if serotonin syndrome is suspected.
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Convey to your healthcare provider if you're taking any of the next simply because these medications communicate with Viagra® and generic Viagra®:
The hydromorphone in DILAUDID INJECTION might increase the frequency of seizures in sufferers with seizure disorders and may increase the possibility of seizures transpiring in other clinical configurations affiliated with seizures.